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Generalized myasthenia gravis (gMG) is the most common form of myasthenia gravis (MG), a rare autoimmune neuromuscular disease that interrupts the communication between the nerves and muscles, causing muscle weakness and tiredness.
gMG is sometimes called a “snowflake disease” because symptoms can vary from person to person.
Common symptoms include:
gMG interrupts signals between your nerves and muscles.
Acetylcholine attaches to a receptor on the muscle surface called the acetylcholine receptor (AChR), which helps tell the muscles to move. Other receptors, including muscle-specific tyrosine kinase (MuSK), also help the muscles receive the message.
In gMG, sometimes harmful anti-AChR and anti-MuSK antibodies can be formed against the AChR and MuSK muscle receptors that are important for relaying messages from nerves to muscles.
People with harmful antibodies that target AChR have anti-AChR antibody-positive gMG.
Found in ~80% of people with gMG
People with harmful antibodies that target MuSK have anti-MuSK antibody-positive gMG.
Found in ~6% of people with gMG
Normally, the purpose of IgG antibodies is to help defend your body against infection and disease that can be caused by foreign proteins such as viruses and bacteria.
FcRn extends the time IgG antibodies are in your body. This is meant to help protect your body from those foreign proteins that can cause illness.
In gMG, the body can mistakenly make harmful IgG antibodies—such as harmful anti-AChR and anti-MuSK antibodies—that interfere with the signal between your nerves and muscles. FcRn can also help keep harmful IgG antibodies in your body longer. This allows them to continue to disrupt the signals between your nerves and muscles.
Health care is a vital aspect of maintaining overall well-being, encompassing a range of services from preventive care
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